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Fourth, discrepancies in outcome datasuch as mismatched sample sizes and overlapping datasets between discovery and replication phases due to FinnGencompromised the validity of their conclusions

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Among them, HLA alleles, especially the HLA-DR1 and HLA-DR4 loci, play an important role in the development of RA by mechanisms that may be related to the formation of citrullinated antigens and immune tolerance of CD4 + T cells (Wysocki et al., 2020

Phase 3 trial results have been recently published for the first pills and they are quite promising