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Short-acting GLP-1 RAs (e.g., exenatide, lixisenatide) were found to have a reduced impact on overnight and fasting blood glucose levels, while long-acting GLP-1 RAs (liraglutide, exenatide once weekly, dulaglutide, and semaglutide) were found to have an increased effect and better coverage on overnight and fasting blood glucose and HbA1c levels [18]

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Subcutaneous semaglutide treatment led to an increased number of retinopathy complications in the SUSTAIN-6 cardiovascular outcomes trial (81)