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She notes that ingredients like high concentrations of glycolic acid, fragrance, and certain essential oils are more likely to cause irritation, so if your skin tends to react easily, start slowly and look for formulas that pair brightening ingredients with barrier-supportive hydrators and soothing ingredients rather than going all-in on intensive exfoliation

PMID 15212755

In the last step, transport proteins eliminate the drug conjugate from the body

Capacity-Limited Elimination For drugs that exhibit capacity-limited elimination (eg, phenytoin, ethanol), clearance will vary depending on the concentration of drug that is achieved ( Table 31 )

10.1136/bcr-2022-251321 5