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More interestingly, male Sprague-Dawley rats were randomly divided into the normal control (NC) group, high-fat (HF) group, and HF+Lira (GLP-1RA) group

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B-cell Activating Factor (BAFF) and A Proliferation-Inducing Ligand (APRIL) are critical cytokines responsible for B-cell survival and differentiation, and their overexpression in SLE supports proliferation of autoreactive B cells (140, 141)

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