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Average plasma levels of other essential amino acids such as Leucine (U:82.3 mol/L, K:75.5 mol/L), Isoleucine (U:43.0 mol/L, K:37.1 mol/L) and Histidine (U:75.8 mol/L, K:74.9 mol/L) were also considered at the very low limits for healthy adolescents, except for Phenylalanine (U:37.6 mol/L, K:43.3 mol/L) and Methionine (U:18.7 mol/L, K:16.9 mol/L), both of which fall within normal expected values, on average, regardless of disease status (Fig

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The potential mechanism responsible for the increasing blood levels of 25(OH)VD could be that the improvement in the GSH status reduces oxidative stress and upregulates vitamin D-metabolizing genes, thereby increasing blood levels of 25(OH)VD (Figure 2)