Semaglutide is causing a social media frenzy
These are controlled study results, not long-term real-world data
For a deeper explanation of weight loss plateau on semaglutide, this is one of the most common reasons people start looking for another option
By mimicking the natural hormone GLP-1, it helps regulate blood sugar levels and reduces appetite

What we know: GI side effects are common but typically improve after 36 months No deaths or major safety signals through 80104 weeks across two large trials Metabolic improvements (glucose, blood pressure, lipids) are substantial and sustained Discontinuation rate: 11.3% in general obesity population (TRIUMPH-1) better than initially feared from TRIUMPH-4's 18.2% 104-week extension shows continued weight loss to 30.3% no plateau at 80 weeks What we don't know: Full 2-year safety dataset (pending publication) Whether dysesthesia resolves or persists long-term Cardiovascular outcomes (trial ongoing) Weight regain trajectory after stopping Very rare adverse events requiring broader use to detect The bottom line: Retatrutide offers superior weight loss compared to existing medications and TRIUMPH-1's 11.3% discontinuation rate suggests the tolerability picture is better than TRIUMPH-4's osteoarthritis cohort implied

Severe side effects and warnings In clinical trials, serious side effects with retatrutide were uncommon, but they did occur