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Whether high folic-acid intake or high folate status causes altered renal handling of holoTC and increased urinary excretion of vitamin B-12 remains to be investigated

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Mild cirrhosis (Child-Pugh A) may permit cautious GLP-1 use, but moderate-to-severe stages carry significant risks of hypoglycemia and drug accumulation

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[7] In June 2011, a review of two large, randomized controlled trials, the Prostate Cancer Prevention Trial (PCPT) and the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) trial prompted the FDA to alert healthcare professionals of the potential risk of an increased incidence of high-grade prostate cancer in patients receiving finasteride or dutasteride treatment