Acetylation modulates N-terminal autoproteolytic processing of SnCE1 The data shown above indicate lysine acetylation in wild type SnCE1 prohibits proteolytic processing, while all non-acetylated mutants, including SnCE1 Y212A and SnCE1 C256A, show proteolytic processing as visible by immunoblotting with a specific anti-SnCE1 antibody (Figs
As the worlds populations are rapidly heading toward an aging society and human life spans are increasing, this problem will certainly be of greater magnitude in the foreseeable future
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