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Lancet 391 , 155167 (2018)

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The British Society for Haematology emphasises that treatment should not be delayed whilst awaiting confirmatory test results if clinical suspicion of B12 deficiency is high, particularly when neurological symptoms are present

IGF-1 exerts protective effects over mitochondria by preserving it from the oxidative damage generated by augmented metabolism, and increasing ATP synthesis and reducing intramitochondrial production of free radicals [105107]