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doi: 10.1127/entomologia/2023/1686 59 LiY

K.TandonI.AgrawalL.HongyiC.BhattacharyyaS

In some analyses, early initiation is associated not merely with neutral cardiovascular outcomes but with active cardiovascular benefit, a finding that aligns with the known role of estrogen in maintaining vascular elasticity, endothelial function, and lipid metabolism [12]

Additionally, intact glutathione may be absorbed via specific peptide transporters in the small intestine [12][14]

Therefore, the complementary mechanisms of action of an SGLT2 inhibitor and a GLP1-RA (through its effect to reduce appetite and possibly also its ability to slow gastric emptying) may provide an attractive approach for obesity treatment (Fig