AS-IV also activates AMP-activated protein kinase (AMPK), promotes TXNIP degradation, and inhibits TXNIP activity, protecting endothelial cells from TXNIP/NLRP3 inflammasome-induced damage (Zhao Y
There are evidences of fetus toxicity in animal studies, but a few studies have reported a normal birth and no adverse outcomes in women exposed to GLP1RAs in their first terms of pregnancy [47, 48]
TA664 for liraglutide 3.0 mg) recommend considering GLP-1 agonists for adults with a BMI of 35 kg/m or more (or 32.5 kg/m or more for people from South Asian, Chinese, other Asian, Middle Eastern, Black African or African-Caribbean family backgrounds), or a BMI of 30-34.9 kg/m with at least one weight-related comorbidity
This modification allows IGF-1 LR3 to remain free-floating in the bloodstream and exert more direct anabolic effects (Jones & Clemmons, Endocrine Reviews )
Already sent this off to a long list of friends/family using GLP-1s
doi: 10.1038/s41573-021-00367-2 143 RuscicaMSirtoriCRCarugoSBanachMCorsiniA