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Gastaldelli A, Cusi K, Fernandez Lando L, Bray R, Brouwers B, Rodriguez A

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HDL cholesterol modestly increased across the dose range, while LDL cholesterol showed minimal change a pattern consistent with weight-mediated lipid improvements rather than direct drug effects on LDL pathways

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Dual GLP-1/GIP receptor agonists, such as tirzepatide, simultaneously activate both receptors, thereby potentiating glycemic control, promoting weight loss, and ameliorating metabolic dysfunction