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Frontiers in Nutrition, 12
Live cell imaging of cytosolic NADH/NAD(+) ratio in hepatocytes and liver slices
(146) observed significant blood-to-brain influx for non-acylated GLP-1 mimetics like exendin-4 and lixisenatide, whereas acylated GLP-1 analogues such as liraglutide and semaglutide showed minimal blood-brain barrier penetration in mice
Lengsfeld S, Burkard T, Meienberg A, Jeanloz N, Vukajlovic T, Bologna K, Steinmetz M, Bathelt C, Sailer CO, Vogt DR, Hemkens LG, Speich B, Urwyler SA, Kuhne J, Baur F, Lutz LN, Erlanger TE, Christ-Crain M, Winzeler B
& Schofield, C
Many clinicians actively recommend PPI therapy for semaglutide users with significant reflux symptoms
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