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Acetaldehyde induces cytotoxicity via triggering mitochondrial dysfunction and overactive mitophagy

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60 Risk factors for experiencing DKA with SGLT2-I are not fully understood but may include type 1 diabetes, treatment with insulin, volume depletion, alcohol use, illness, and those in postoperative status

First identified in 2012, it is defined by iron-dependent lipid peroxidation and the accumulation of lipid peroxides ( 2.1 Core machinery of ferroptosis The regulation of ferroptosis involves several key components, including GPX4, the cystine/glutamate antiporter system (System Xc-, composed of SLC7A11 and SLC3A2 subunits) and acyl-CoA synthetase long-chain family member 4 (ACSL4) ( Figure 1 )

Combination-therapy with bedtime nph insulin and sulphonylureas gives similar glycaemic control but lower weight gain than insulin twice daily in patients with type 2 diabetes