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However, the weight loss observed in the SELECT study (9.4%) was lower than that seen in previous STEP studies.23 The study design, which was not focused on obesity, may have influenced the lower-than-expected weight reduction, which did not parallel the trend in MACE reduction

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*Correspondence: Michael Camilleri, [email protected] This article was submitted to Gastrointestinal and Hepatic Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Cagrilintide is usually discussed as a long-acting amylin-based treatment under study

Dihexa offers a mechanistically intriguing but unvalidated probe for HGF/c-Met neurobiology, with the critical caveat that its core published evidence is under question

In addition, avoiding tanning beds and performing regular self-skin checks are also important preventive measures