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We studied VPA toxicokinetics using a nonlinear mixed-effects model-based population approach and modeled individual plasma VPA/blood lactate concentration relationships

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To test whether this newly identified L1FnIII-2 interaction is functionally important for receptor activation, we introduced multiple mutations in the L1 hairpin of IGF1R (K164A, T166A, N169A, and Y171A), deleted the entire L1 hairpin (163174), or replaced this L1 hairpin with a short GSGS loop (163GS) to disrupt this interaction

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