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Subcutaneous injection is the most common research-context format today, but no published human pharmacokinetic study has formally characterized subcutaneous AOD-9604 (this gap was specifically called out in FDA's December 2024 review)

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However, no difference between ME/CFS patients and controls was found with respect to autoantibodies against serotonin, angiotensin, endothelin, mu-opioid, and dopamine (503, 504)

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