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Sex hormone-binding globulin regulation of androgen bioactivity in vivo: Validation of the free hormone hypothesis

The salt bridge between R283 6.55 and E124 3.33 exists in both antagonist-bound and active ghrelin receptor structure, however, in contrast to antagonist compound 21, ghrelin or GHRP-6 pushes the side-chain of R283 6.55 to swing away from the receptor helical core, which induces rotation of TM6 that initiates the cascade of conformational changes in receptor activation (Fig

Addissouky, University of Menoufia, Egypt Updates Copyright 2026 Tan, Liu, Liang and Chen

eLife 14 , RP106217 (2025)

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