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The numbers in the hundreds of thousands or million plus range would be very difficult if not impossible to conduct randomized clinical trials on

(2004) Characterization of an adrenocorticotropin (ACTH) receptor promoter polymorphism leading to decreased adrenal responsiveness to ACTH

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However, their use may cause gastrointestinal side effects, especially nausea, which is dose-related and may be prevented by slow dose escalation [6]