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9,12 Additionally, GLP-1RAs activate nitric oxide (NO) synthase expressed in Schlemms canal and the trabecular meshwork, increasing NO production to reduce trabecular meshwork contraction, improving aqueous outflow

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When food remains in the stomach longer than usual, it can lead to feelings of fullness, abdominal distension, and bloating

The connection between Pso with obesity and metabolic disorders has generated increased research interest in using GLP-1RA for Pso treatment

Appreciating the triple agonist action helps explain why retatrutide might succeed in people that have done poorly on other therapies