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For GHK-Cu specifically, some researchers prefer morning administration to align with natural growth hormone patterns

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10.1016/b978-0-12-801022-8.00011-8 Int

15 In addition, our preliminary findings in a skin permeability test using a 3-dimensional cultured skin model show that at least some of the GSSG in the stratum corneum side penetrates through the epidermal barrier (data not shown)

It may achieve this by upregulating vascular endothelial growth factor (VEGF), an endogenous protein responsible for stimulating the growth of new blood vessels [4]

doi: 10.1038/nrc3431 95 BanningAKippASchmitmeierSLwingerMFlorianSKrehlSet al