10.1056/NEJMsr1606602 32 LeeH.LeeY.KimJ.AnJ.LeeS.KongH.et al (2018)
For instance, a single-center study involving 200 type 2 diabetes patients, stratified by UACR categories (normal, micro-, and macroalbuminuria), found that the combined measurement of C16, C18:1, and C3 achieved an area under the receiver operating characteristic curve (AUC) of 0.89 for early DKD diagnosis, significantly outperforming UACR (AUC = 0.76) [147,148,149,150]
MOTS-C is a 16-residue peptide encoded not in nuclear DNA but in the mitochondrial 12S rRNA region, making it one of a small class of mitochondrial-derived peptides
Patients with pre-existing eye disease should discuss this risk with their provider
R.OlssonS.OrreR.LansnerA.et al (1998)
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