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Novo Nordisk filed a New Drug Application with the FDA for CagriSema in late December
Because no analogous enzyme exists for cysteine sulfide, each cysteine SH can be used only once.
Bayley EM, Ivy ML, Shewale JB, Ge PS, Antonoff MB, Francis AM, Hofstetter WL, Mehran RJ, Rajaram R, Rice DC, Roth JA, Sepesi B, Vaporciyan AA, Walsh GL, Lee JJ, Louie BE, Swisher SG
For positions V12 and F112, many of the tested variants exhibited wild-type-level dehydratase activity (Fig
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