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Retatrutide targets three hormone receptors : GLP-1, GIP (glucose-dependent insulinotropic polypeptide), and glucagon

doi: 10.1056/NEJMoa2206038 104 GarveyWTFriasJPJastreboffAMLe RouxCWSattarNAizenbergDet al

The findings were presented at the American Diabetes Association 86th Scientific Sessions

Comparison with other GLP-1s As compared to other GLP-1RAs, orforglipron is a direct and orally active small molecule, rather than a peptide

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Zhaoping Li, MD, the chief of the Division of Clinical Nutrition at UCLA Health and director of the UCLA Center for Human Nutrition in Los Angeles, also welcomed the news