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Serum UA levels were considerably lower in patients at risk of developing PD (UA: 261.6 M, controls: 338.7 M) according to a search for blood alterations during the prodromal period of PD (Katunina et al., 2023)

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This dysfunction is not a passive consequence but an active process whereby viral components and the resulting inflammatory milieu directly impair mitochondrial integrity, fueling a vicious cycle of immune exhaustion and viral persistence