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That said, retatrutide remains investigational and unlicensed, and the full safety data deserve careful scrutiny once peer-reviewed
22 This highlights the importance of continuous pharmacist involvement to assess tolerability, determine when dose adjustments or therapy changes are warranted, and guide patients through individualized management strategies
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Bacteriostatic water mitigates this, but the fewer punctures, the better
Fifth, cost-effectiveness analyses are critical given the high price of current GLP-1 RAs and the large potential treatment population: preliminary health-economic models suggest acceptable cost-effectiveness ratios in high-fibrosis patients with comorbid type 2 diabetes and cardiovascular disease, but robust data in broader MASLD populations are lacking
