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(7) These events may depolarize the Kisspeptin-10 neurons, possibly leading to the depolarization of the GnRH neurons and modulating gonadotropin release, to some extent

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While insulin and IGF-1 share structural similarities and activate overlapping intracellular signaling pathways, such as the PI3K/Akt and MAPK pathways, they exhibit differential localization within the brain, which may impact their distinct roles in neuronal function and mood regulation [94, 95]

A., Farhood, A

The proposed mechanism involves maintaining synaptic vesicle integrity, competing for receptor sites, and potentially substituting for depleted neurotransmitters