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3.6 Epithelialmesenchymal transition EMT is a complex biological process in which renal tubular epithelial cells lose their characteristic features and acquire mesenchymal-like properties ( In DKD, in response to severe or persistent inflammation, TECs undergo EMT through various signaling pathways, such as TGF-, Wnt/-catenin, PI3K/Akt, JAK/STAT, and Notch pathways ( Nevertheless, the precise detection of EMT in renal tissues remains challenging, and the development of effective anti-EMT therapies has been impeded for a long time

Do not stop the use of this medicine without consulting your doctor

Many antioxidant nutrients (folic acid, and vitamin B) and other dietary substances (green tea, and alcohol) are known to affect DNA methylation 43,44

Santini, S

Luo J, Bai L, Tao J, Wen Y, Li M, Zhu Y, et al

Peer review Peer review information Nature Chemical Biology thanks Tomohiro Sawa, Christopher Switzer and the other, anonymous, reviewer(s) for their contribution to the peer review of this work