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doi: 10.1016/j.ejmech.2020.112954 65 OuelletteMMZhouSYanY

A review by Cardinali highlights melatonins potential in counteracting neurodegeneration and frailty in the elderly, noting melatonins excellent safety profile and low toxicity even at high doses ( Melatonin supplementation in older adults must be timed correctly to avoid phase shifts that could worsen circadian timing if misused

In a study involving rats with hind limb ischemia, BPC-157 treatment was found to increase the expression of VEGFR2, subsequently activating the VEGFR2-Akt-eNOS pathway

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This vasodilator increases the availability of inflammatory mediators (TNF-, L-selectin) which, at high concentrations, can damage epithelial cells and lead to bronchial contraction (101)