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Kumar A, Davuluri G, Silva RNE, et al
At the tumor site, PMIR effectively inhibits glutamine metabolism in tumor cells, leading to an elevation in intratumoral glutamine levels and improving immune cell functionality, ultimately reshaping the immunosuppressive TME and evoking robust immune responses [204]
The activation of D14 is initiated by the intact SL molecule, which induces a destabilized conformation in D14 by interfering with the formation of its catalytic triad, rather than by its hydrolysis intermediates or products 24