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In a 48-week clinical trial, higher doses consistently led to greater average weight loss: Weight loss by dose (48-week clinical trial) In this trial, at the highest dose (12 mg), people lost an average 24% of their starting weight on average

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Patients showed elevated insulin levels and a decrease in systolic blood pressure

Others may be curious because of cost considerations, access limitations, or a preference for gradual changes rather than rapid shifts in appetite or digestion