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GLP-1 Drugs Show a Rare but Serious Vision-Loss Signal A large observational study found that adults with type 2 diabetes starting GLP-1 medications had a slightly higher risk of ischemic optic neuropathy than patients using two other classes of diabetes drugs

doi: 10.1016/S0736-5748(03)00030-3 22 TerockJHannemannAKlinger-KnigJJanowitzDGrabeHJMurckH

Rhabdomyolysis associated with the use of tirzepatide

These effects are real and can be significant in the short term

Gln contributes to the biosynthesis of proteins and nucleotides as a nitrogen source, enabling tumor cell survival and proliferation

Furthermore, the number of neuron-derived orphan receptor 1 (NOR1) which can modulate VSMC proliferation, is decreased by GLP-1RAs in a dose-dependent manner in mice [121]