Prostate cancer cells co-cultured with adipocytes increase expression of IL1- to stimulate adipocyte lipolysis in a vicious positive feedback loop that decreases prostate cancer cell sensitivity to docetaxel and upregulates prostaglandin E2 (PGE2) synthesis in adipocytes, a prostate cancer pro-survival signal (212)
Why does concentration matter more than vial size alone
Through low-temperature slow extraction, the fresh aroma of spices is preserved, then multiple layers of filtration remove impurities and sediments, followed by long-term constant temperature fermentation to fully blend and mature the original fragrance, weakening sharp odors and making the aroma richer, more delicate, and longer-lasting mellow
Weight of evidence: Overall evidence is ModerateLow : encouraging signal from a historical cross-over trial but limited by small samples and lack of biomarker data
World J Gastroenterol (2015) 21:11597608
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