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and what is most important, without any increase in weight gain, reduction in morbidity and mortality, or reduction in hospital stay

Most of the supporting work sits in animal models, and the article calls translating those findings to humans speculative

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A widely cited extension of the STEP 1 trial found that participants who stopped semaglutide regained roughly two-thirds of their weight loss within a year

Oxidative stress-induced formation of methionine sulfoxide can spontaneously react with hydroxyl radical and generates methyl radical that non-specifically and non-enzymatically methylate DNA cytosine and may affect the epigenome 38

This can diminish the effect of oral contraceptives such as the pill