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Magkos F, Fabbrini E, Mohammed BS, Patterson BW, Klein S (2010) Increased whole-body adiposity without a concomitant increase in liver fat is not associated with augmented metabolic dysfunction

Genetic Variation Some people are naturally more efficient at producing and recycling glutathione than others

In parallel, inactivity can enhance non-mitochondrial reactive oxygen species production through NADPH oxidases, disrupt calcium homeostasis, and impair mitochondrial quality-control mechanisms such as mitophagy