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We included peer-reviewed randomized controlled trials, meta-analyses, and high-quality narrative or systematic reviews written in English that evaluated the effects of GLP-1 receptor agonists (liraglutide, semaglutide, or related analogues), as well as dual GIP/GLP-1 receptor agonists (such as tirzepatide), exercise training, or their combination on weight loss, body composition, metabolic, or cardiovascular outcomes in adults with obesity or type 2 diabetes

One notable real world example comes from the digital weight loss clinic Embla, where patients achieved an average 14.8% weight loss at 64 weeks using a maximum mean semaglutide dose of 0.77 mg, about 36% of the standard cumulative dose, while maintaining effectiveness

If they're prescribed just for weight loss, coverage might be harder to get

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