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Joel Habener & John Eng Contributed to incretin biology and the discovery of exendin-4, a critical precursor in GLP-1 drug development

The two major factors that can affect DNA methylation include genes (non-modifiable) and the environment (modifiable), of which diet is a key factor

[4] [2] Clinical observations suggest the hair loss typically manifests as telogen effluvium a form of diffuse hair shedding that occurs when a significant number of hair follicles enter the resting (telogen) phase prematurely

However, they can also trigger side effects, including changes to hair and skin quality

Dose adjustments and titration protocol changes are normal parts of GLP-1 treatment management and can often address tolerability issues

DR occurs in both males and females with diabetes, but males appear to be at a slightly higher risk (9)