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Dapagliflozin Initial Combination Therapy With Metformin HCl Extended-Release A total of 1236 treatment-naive adult patients with inadequately controlled type 2 diabetes mellitus (HbA1c 7.5% and 12%) participated in 2 active-controlled trials of 24-week duration to evaluate initial therapy with dapagliflozin 5 mg (NCT00643851) or 10 mg (NCT00859898) in combination with metformin extended-release formulation

This is particularly important for obese patients with diabetes

doi: 10.1200/JCO.2012.44.8738 11

This metabolic adaptation means you may need fewer calories to maintain your new weight than someone who was always at that size

This can make it harder to identify your true appetite baseline and adjust your dose appropriately

The metabolite BH4 controls T cell proliferation in autoimmunity and cancer