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Jonik et al.) Its well-characterized pharmacokinetics and receptor selectivity have made it a standard in peptide-based metabolic research (Hall et al.)

In hypoxic epithelial ovarian cancer, as a transcription factor of IGF-1, highly expressed ELF3-mediated secretion of IGF-1 and VEGF promoted endothelial cell proliferation, migration and tumor angiogenesis through activation of the tyrosine kinase pathway, whereas ELF3 silencing attenuated angiogenesis and tumorigenesis in a xenograft mouse model, demonstrating the pro-vascular effect of IGF-1 (39)

[DOI] [PMC free article] [PubMed] [Google Scholar] 12.Chen CH, Huang YK, Jaw FS

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It may also have potential as a treatment for age-related cognitive decline