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This drives neuronal death, perihematomal edema, and prolonged neuroinflammation 49

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In an early phase 2 study, one patient receiving the medication developed renal dysfunction due to presence of low molecular weight substances and a purified version was designed ( (4) Targeting Inflammation Continual background inflammation contributes to organ damage in patients with SCD

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Therefore, based on their solubility in aqueous environments, the combination of TA and KGN in hydrogels could realize on-demand drug release to sequentially recruit MSCs and stimulate chondrocyte differentiation to accelerate new cartilage formation