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Another way is when the different estrogens are out of balance

BR96-DOX was advanced to a Phase II human clinical trial in metastatic breast cancer (Tolcher et al., 1999)

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176 As an extensive discussion of these drugs is beyond the scope of this review, we refer the reader to the referenced work and focus our discussion on two less frequently mentioned interventions for which preclinical and clinical experience has been made by one of us (MKF)

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217 p53 can also increase tau protein phosphorylation in human cells to promote neuroblastoma cell death and the formation of neurotoxic neurofibrillary tangles