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This article was supported by the CAMS Innovation Fund for Medical Sciences (2019-I2M-5-055)

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CA19-9, a blood biomarker for the detection of PC, has high specificity for PC detection but is not suitable for screening [268, 270, 271]

Hypoxia-inducible factor-1 (HIF-1) also exhibits dual regulation: during acute hypoxia, it stimulates eNOS expression to ensure adequate NO production but may suppress eNOS in chronic hypoxia, causing maladaptive vascular changes (McQuillan et al., 1994

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