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Coverage requires BMI 30 or 27 with comorbidities and documentation of prior lifestyle modification attempts

Several placebo-controlled clinical trials have shown pomegranate can lower total cholesterol and LDL levels in people with high cholesterol and may also improve other parameters indicative of atherosclerosis

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Future directions Future research should explore combination strategies, including dual and triple therapy regimens pairing tirzepatide with other agents including sodium-glucose cotransporter-2 inhibitors and the non-steroidal mineralocorticoid receptor antagonist, finerenone, which have been shown to offer additive cardiorenal protection alongside GLP-1RAs [35]

Step 1: Baseline Assessment Before starting therapy, patients undergo baseline laboratory testing including blood glucose, lipid profile, thyroid function, and liver and kidney function tests