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In a recent phase 3 trial with patients with T2D and inadequate glycaemic control, the mean percentage change from baseline body weight with the 12-mg dose of retatrutide at 40 weeks was -15.3% [19]

In line with this hypothesis, recent studies suggest that the BDNF/pro-BDNF ratio is altered in neurological diseases, leading to an imbalance in serum levels of pro- and mBDNF, which may play an important role as biomarkers in these pathologies 8,25,26,27

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Methionine synthase plays a role in the production of purines and pyrimidines, which are building blocks in DNA synthesis

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