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10.4330/wjc.v17.i4.104717 61 PerleyM

most importantly, muscle is metabolically active, requiring energy to sustain itself

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In mice, HCD elevated plasma cholesterol and significantly improved survival (52.5% to 90%), independent of immune modulation.Hepatic transcriptomics revealed metabolic reprogramming, including upregulation of oxidative phosphorylation and glutathione-mediated antioxidant pathways, and suppression of endoplasmic reticulum proteostasis