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Extensive published preclinical research, primarily from rat and mouse models

The effect was very strong, nearly 30% reduction with metformin alone (first line treatment for type 2 diabetes) but an additional 40% with GLP-1 receptor agonists (eg, Wegovy [semaglutide, Novo Nordisk]), and unexpectedly it was effective for all asthma patients, including those with higher or lower BMI, and with all different types of asthma, Chloe I

If symptoms occur, they usually relate to the underlying cause of the elevated level

The prevalence of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction in men and women with type 2 diabetes: a systematic review and meta-analysis

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