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10.3389/fnagi.2014.00030 Front

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Certainly, human patients with T2DM display a blunted incretin effect of GLP-1, and defects in meal-induced intestinal GLP-1 secretion (91), suggesting that the paracrine action of alpha-cell-derived GLP-1 may be necessary to combat this diminished peripheral incretin action of gut-derived GLP-1