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This anti-inflammatory role is further corroborated by evidence showing that APOM-S1P inhibits ox-LDL-induced inflammation in HUVECs via the S1PR2-mediated PI3K/Akt pathway[57] and that APOM/ mice exhibit significant increases in pro-inflammatory proteins like iNOS, NF-B, and IL-1 [58]

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For the inhibition assay, the concentrations of substrates in the cell lysate treated with different concentrations of inhibitors were determined via LC-MS, and the calculation methods for the uptake rate and UR were similar to those in the substrate assay

The AF contains concentric lamellae mainly composed of collagen type I, elastin fibres, and fibroblast-like cells

2002, 26: 175-10.1165/ajrcmb.26.2.4501

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