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Because psoriasis is an immune disease, the idea of immune modulation is tempting, but modulation is not the same as the targeted IL-17/IL-23 blockade that works, and a peptide that nudges immunity broadly could just as easily do nothing or worsen an autoimmune process

One of them compared 3ppm Pal-KTTKS with 700 ppm (0.07%) retinol and found that they showed similar wrinkle improving ability with the peptide showing better skin tolerability

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The four peptides (Argireline, Acetyl Tetrapeptide-5, Palmitoyl Hexapeptide-12, Glutathione) each address a different mechanism that becomes more relevant as oestrogen declines

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An 8-week on, 4-week off schedule provides predictable timing