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Vitamin B12 is an essential nutrient that supports red blood cell formation, neurological function, and DNA synthesis

This suggests that non-responders were less severely affected by ME/CFS at baseline, and that the main positive effect of nasal B12 administration occurs in more severely affected patients

doi: 10.1016/j.fct.2017.06.044 185 HanZCenCOuQPanYZhangJHuoDet al